Oral Combined HRT
Oral combined HRT tablets contain both oestrogen and progestogen. They are prescribed for women who still have a uterus, because the progestogen protects the womb lining from thickening and reduces the risk of endometrial cancer. Tablets are available in two main types: sequential (cyclical) and continuous combined.
Comparison of Oral Combined HRT Options
| Type of Oral Combined HRT |
How It Works |
Benefits |
Potential Drawbacks |
When Recommended |
Common NHS Brands |
| Sequential Combined HRT - oral |
Oestrogen taken daily; progestogen added for part of the month (usually 10–14 days). Mimics natural cycle and results in a monthly withdrawal bleed. |
Provides womb protection
Mimics natural cycle
Effective symptom relief
Simple daily tablet
|
Monthly bleeding, which some women find inconvenient
Side effects: breast tenderness, headaches, mood changes. Oral oestrogen increases risk of blood clots compared to patches/gels
|
Best for perimenopausal women or those in the early years after menopause who are still having irregular periods |
Elleste Duet®, Femoston® 1/10 or 2/10 |
| Continuous Combined HRT - oral |
Oestrogen and progestogen taken together every day. Provides continuous womb protection and usually stops monthly bleeding. |
No monthly bleed Simple daily regimen Effective symptom relief Familiar tablet form |
Side effects: breast tenderness, headaches, mood changes. Small increase in breast cancer risk with long-term use. Oral oestrogen increases risk of blood clots compared to patches/gels Metabolised by liver, unsuitable for some women |
Best for postmenopausal women (at least 12 months after last natural period). Not usually advised in early perimenopause due to unpredictable bleeding |
Elleste Duet Conti®, Femoston® Conti, Premique® Low Dose |